Glyxambi

Generic Name: empagliflozin and linagliptin (EM pa gli FLOE zin and LIN a GLIP tin)
Brand Names: Glyxambi

What is Glyxambi?

Glyxambi contains a combination of empagliflozin and linagliptin are oral diabetes medicines that help control blood sugar levels. Empagliflozin works by helping the kidneys get rid of glucose from your bloodstream. Linagliptin works by regulating the levels of insulin your body produces after eating.

Glyxambi is used together with diet and exercise improve blood sugar control in adults with type 2 diabetes. This medicine is not for treating type 1 diabetes.

Glyxambi is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

Important information

You should not use Glyxambi if you have severe kidney disease (or if you are on dialysis), if you have ever had a severe allergic reaction to empagliflozin or linagliptin, or if you are in a state of diabetic ketoacidosis.

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Call your doctor at once if you have signs of a serious side effect, such as severe pain in your upper stomach spreading to your back, vomiting, fast heart rate, dizziness, feeling very thirsty or hot, decreased urination, heavy sweating, or hot and dry skin.

Before taking this medicine

You should not use Glyxambi if you are allergic to empagliflozin and linagliptin, or if you have:

severe kidney disease (or if you are on dialysis);

a history of severe allergic or skin reaction after taking linagliptin; or

if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure Glyxambi is safe for you, tell your doctor if you have ever had:

heart problems;

kidney disease;

liver disease;

a pancreas disorder;

low blood pressure;

gallstones;

high cholesterol or triglycerides (a type of fat in the blood);

alcoholism;

genital infection (penis or vagina);

if you are on a low salt diet; or

if you are 65 or older.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether empagliflozin and linagliptin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Glyxambi?

Take Glyxambi exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Glyxambi is usually taken in the morning. You may take this medicine with or without food.

Your blood sugar will need to be checked often, and you may also need to test the level of ketones your urine. Glyxambi can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have ketones in the urine.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication.

Glyxambi can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Glyxambi.